Ongoing Research
SMASH Dementia!
This is a study and patient registry designed to help better understand how sleep, mood, and arousal symptoms are interconnected in patients with dementia and healthy aging participants. The study is currently funded through a Research Program of Execellence through the Iowa Neuroscience Institute and the Roy Carver Charitable Trust. For more information, please see the "SMASH Dementia!" tab.
Human Autopsy Research
The Aldridge lab, as well as multiple other dementia labs across the University of Iowa, rely on individuals that choose to donate their brain to science. Please consider signing up now to eventually donate your brain- regardless of your age or state of health. There is no better donation and we need your help. For more information, speak with your UIHC neurologist, contact Dr. Aldridge, or CLICK HERE for more information about our brain bank.
Dr. Aldridge's current research investigates how different protein types, such as alpha-synuclein, amyloid, tau and TDP-43 impact cell loss, cellular morphology, synapse loss and individual patient symptoms. However, any donation will contribute to countless research projects, helping not only those with dementia but many types of brain diseases. We thank you for your consideration.
Upcoming Research Projects
Our team is applying for funding to start treatment trials in some populations. Check back here for more details in the future.
Completed research projects, publications and reviews on these diseases
(These are our human research publications, to see mouse research see the "Mouse Research" tab.)
Gibbons, C. H., T. Levine, C. Adler, B. Bellaire, N. Wang, J. Stohl, P. Agarwal, G. M. Aldridge, et al. & R. Freeman (2024) Skin Biopsy Detection of Phosphorylated alpha-Synuclein in Patients With Synucleinopathies. JAMA.
Zhang, Q., Schultz., J. Aldridge, GM., Simmering, JE., Kim, Y-C, Ogilvie, AC, Narayanan, NS. Covid-19 case fatality and Alzheimer’s Disease. (2021) J. Alzheimer’s Dis. 2021;84(4):1447-1452. PMID: 34690147
Halhouli, O., Zhang, Q., Aldridge, G.M. Caring for patients with cognitive dysfunction, fluctuations and dementia caused by Parkinson’s disease. 2022. Progress in Brain Research. ISSN 0079-6123. (Book chapter)
Zhang Q*, Aldridge GM*, Narayanan NS, Anderson SW, Uc EY (2020). Approach to Cognitive Impairment in Parkinson's Disease. Neurotherapeutics. 2020 Oct;17(4):1495-1510 Review. PubMed PMID: 33205381.
Zhang, Q., Schultz., J. Aldridge, GM., Simmering, JE., Narayanan, NS. Covid-19 case fatality and Parkinson’s disease. (2020) Movement Disorders. Nov;35(11):1914-1915 PMID: 32954522
Aldridge, G.M., Birnschein, A., Denburg, N.D., Narayanan, N.S. (2018). Parkinson’s disease dementia and dementia with Lewy bodies have similar neuropsychological profiles. Frontiers in Neurology. Mar 12;9:123 PMID: 29593630 https://www.frontiersin.org/articles/10.3389/fneur.2018.00123/full
Serrano-Pozo, A., Aldridge, G.M., Zhang, Q. (2017). Four Decades of Research in Alzheimer’s Disease (1975-2014): A Bibliometric and Scientometric Analysis. Journal of Alzheimer’s Disease. 2017;59(2):763-783 PMID: 28671119