Welcome to the Aldridge Laboratory:
Dr. Georgina Aldridge is a neurologist and neuroscientist whose specializes in treating and diagnosing patients with cognitive disorders, including those with Lewy Body dementia/Parkinson's disease dementia. In these patients, the protein alpha-synuclein aggregates, leading to severe multi-system symptoms, including hallucinations, loss of smell, dementia, imbalance, fluctuating confusion, and anxiety/depression. Our main goal is to understand the role that pathology and protein misfolding in the cortex plays in the development of these symptoms.
|Dr. Aldridge and her team use 2-photon microscopy to image neuronal structure (dendritic spines, dendrites, and axons) and function (calcium imaging) over time in living mice to evaluate how alpha-synuclein and other proteins involved in neurodegenerative conditions lead to changes in cortical function.|