Featured Content

  • p-synuclein in YFP-H mice on apical dendrites with dendritic spines. mCherry marks injection site.
  • Prefrontal Apicals Prefrontal Apicals in yellow fluorescent protein (YFP) expressing mice.
  • Dendritic spines and axons imaged once per week
  • Dendritic spines and axonal boutons in vivo
  • Alpha-synuclein immunostaining after viral overexpression.
    Alpha-synuclein immunostaining after viral overexpression (green)
  • Alpha synuclein inclusions in the cortex
    Alpha-Synuclein staining in the cortex of Parkinsons dementia patient (brown)
  • Lewy Body
    Lewy Body in subtantia nigra from Parkinson's dementia patient (pink sphere)

Welcome to the Aldridge Laboratory:

Georgina Aldridge

Dr. Georgina Aldridge is a neurologist and neuroscientist whose specializes in treating and diagnosing patients with cognitive disorders, including those with Lewy Body dementia/Parkinson's disease dementia. In these patients, the protein alpha-synuclein aggregates, leading to severe multi-system symptoms, including hallucinations, loss of smell, dementia, imbalance, fluctuating confusion, and anxiety/depression. Our main goal is to understand the role that pathology and protein misfolding in the cortex plays in the development of these symptoms. 
 Dr. Aldridge and her team use 2-photon microscopy to image neuronal structure (dendritic spines, dendrites, and axons) and function (calcium imaging) over time in living mice to evaluate how alpha-synuclein and other proteins involved in neurodegenerative conditions lead to changes in cortical function.

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